铝盐对突触体酶的影响——一项体外动力学研究。
Effects of aluminium salts on synaptosomal enzymes--an in vitro kinetic study.
作者信息
Rao K S
机构信息
Department of Nutrition and Food Safety, Central Food Technological Research Institute, Mysore, India.
出版信息
Biochem Int. 1990 Nov;22(4):725-34.
PMID:1964047
Abstract
Synaptosomal key enzymes, ATPase (Na(+)-K+, Mg2+ and Ca2+ dependent) and AchE, were used as probes to compute IC50-values in order to study neurochemical effects of aluminium salts. Such effects were examined by means of the Toxicity Test Value (TTV), Maximum Chemical Acceptability Value (MCAV) and Omega (omega) value which indicated salt specific toxicity. Kinetics of Ca2(+)-ATPase inhibition by AlF3 was found to be non-competitive.
摘要
突触体关键酶，即三磷酸腺苷酶（依赖于Na⁺-K⁺、Mg²⁺和Ca²⁺）和乙酰胆碱酯酶，被用作探针来计算半数抑制浓度（IC50）值，以研究铝盐的神经化学效应。通过毒性测试值（TTV）、最大化学可接受值（MCAV）和奥米加（ω）值来检测此类效应，这些值表明了盐的特定毒性。发现AlF₃对Ca²⁺-ATP酶的抑制动力学是非竞争性的。
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