Ransmayr G, Bitschnau W, Schmidhuber-Eiler B, Berger W, Karamat E, Poewe W, Kemmler G W
University Clinic of Neurology, University of Innsbruck, Austria.
J Neural Transm Park Dis Dement Sect. 1990;2(4):265-75. doi: 10.1007/BF02252921.
High-speed memory scanning (Sternberg paradigm) was tested in a collective of 20 parkinsonian patients (10 newly diagnosed, untreated patients, duration of the disease 0.5-3.8, mean 1.5 years; 10 levodopa-treated patients, duration of the disease 4.2 to 11, mean 7.6 years). The levodopa-treated patients stopped taking levodopa before the test. There was a tendency towards retarded memory scanning in the patients' collective compared with 20 healthy controls with similar ages and verbal IQs (p = 0.076, Mann-Whitney U test). The mental slowing correlated significantly with bradykinesia and the sum-score of the Columbia University Parkinson Rating Scale (p = 0.021 and 0.019; Spearman rank correlation). Kruskal-Wallis ANOVA revealed a significant mental slowing in the subgroup of patients with Parkinson's disease for greater than 4 years compared with the newly diagnosed patients and the controls (H = 8.54; p = 0.019 and 0.006, Mann-Whitney U test). The findings suggest a mental slowing in Parkinson's disease, which is associated with the progression of parkinsonian motor symptoms and not with depression.
对20名帕金森病患者（10名新诊断的未治疗患者，病程0.5 - 3.8年，平均1.5年；10名接受左旋多巴治疗的患者，病程4.2至11年，平均7.6年）进行了高速记忆扫描（斯特恩伯格范式）测试。接受左旋多巴治疗的患者在测试前停止服用左旋多巴。与20名年龄和语言智商相似的健康对照相比，患者群体存在记忆扫描延迟的趋势（p = 0.076，曼 - 惠特尼U检验）。精神运动迟缓与运动迟缓以及哥伦比亚大学帕金森病评定量表的总分显著相关（p = 0.021和0.019；斯皮尔曼等级相关）。克鲁斯卡尔 - 沃利斯方差分析显示，与新诊断患者和对照组相比，病程超过4年的帕金森病患者亚组存在显著的精神运动迟缓（H = 8.54；p = 0.019和0.006，曼 - 惠特尼U检验）。研究结果表明帕金森病存在精神运动迟缓，这与帕金森病运动症状的进展有关，而非与抑郁有关。
