Pillon B, Dubois B, Bonnet A M, Esteguy M, Guimaraes J, Vigouret J M, Lhermitte F, Agid Y
Clinique de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, Paris, France.
Neurology. 1989 Jun;39(6):762-8. doi: 10.1212/wnl.39.6.762.
To evaluate clinically the slowing of cognitive processing in Parkinson's disease, we used a visual discrimination task consisting of 15 superimposed images of objects. The time needed to identify 12 objects increased by 58% in 70 patients withdrawn from levodopa treatment compared with 20 controls matched for age and education. Perceptual, motor, and psycholinguistic factors, as well as mood, only partially accounted for the slowness of performance. The 15-objects test scores of the parkinsonian patients correlated significantly with both their intellectual impairment and the severity of their parkinsonian disability, but not with the duration of the disease. The scores did not correlate with depression. Levodopa had no effect on the score, although the parkinsonian motor disability score was improved by 54%. The results indicate a cognitive slowing in Parkinson's disease which is probably related to abnormalities of nondopaminergic neuronal systems in the brain.
为了临床评估帕金森病患者认知加工速度的减慢情况，我们采用了一项视觉辨别任务，该任务由15张叠加的物体图像组成。与20名年龄和受教育程度相匹配的对照者相比，70名停用左旋多巴治疗的患者识别12个物体所需的时间增加了58%。感知、运动、心理语言因素以及情绪只能部分解释表现的迟缓。帕金森病患者的15物体测试得分与他们的智力损害以及帕金森病残疾的严重程度显著相关，但与疾病持续时间无关。得分与抑郁无关。左旋多巴对该得分没有影响，尽管帕金森病运动残疾得分提高了54%。结果表明帕金森病存在认知减慢，这可能与大脑中非多巴胺能神经元系统的异常有关。
