Herman Christine, Karolak Wojtek, Yip Alexandra M, Buth Karen J, Hassan Ansar, Légaré Jean-Francois
Division of Cardiac Surgery, Queen Elizabeth II Health Sciences Center, 1796 Summer Street, Rm. 2629, Halifax, Nova Scotia, B3H 3A7, Canada.
Interact Cardiovasc Thorac Surg. 2009 Oct;9(4):654-8. doi: 10.1510/icvts.2008.199521. Epub 2009 Jul 29.
We sought to develop a predictive model based exclusively on preoperative factors to identify patients at risk for PrlICULOS following coronary artery bypass grafting (CABG). Retrospective analysis was performed on patients undergoing isolated CABG at a single center between June 1998 and December 2002. PrlICULOS was defined as initial admission to ICU exceeding 72 h. A parsimonious risk-predictive model was constructed on the basis of preoperative factors, with subsequent internal validation. Of 3483 patients undergoing isolated CABG between June 1998 and December 2002, 411 (11.8%) experienced PrlICULOS. Overall in-hospital mortality was higher among these patients (14.4% vs. 1.2%, P<or=0.0001). The following variables were found to be independent predictors of PrlICULOS: increased age, recent myocardial infarction, preoperative renal failure, cerebral and/or peripheral vascular disease, chronic obstructive pulmonary disease, ejection fraction <40%, previous CABG, triple-vessel and/or left main disease, NYHA class IV symptoms and urgent or emergent status. Subsequent validation of this model demonstrated a c-statistic of 78%. An internally-validated, risk predictive model of PrlICULOS in patients undergoing CABG was constructed. Based on preoperative clinical factors, a scorecard was developed allowing identification of these patients prior to surgery and allowing for strategies aimed at optimizing hospital resources.
我们试图开发一种仅基于术前因素的预测模型,以识别冠状动脉旁路移植术(CABG)后发生术后长时间入住重症监护病房(PrlICULOS)风险的患者。对1998年6月至2002年12月期间在单一中心接受单纯CABG的患者进行了回顾性分析。PrlICULOS定义为初次入住重症监护病房超过72小时。基于术前因素构建了一个简洁的风险预测模型,并进行了内部验证。在1998年6月至2002年12月期间接受单纯CABG的3483例患者中,411例(11.8%)发生了PrlICULOS。这些患者的总体住院死亡率更高(14.4%对1.2%,P≤0.0001)。发现以下变量是PrlICULOS的独立预测因素:年龄增加、近期心肌梗死、术前肾功能衰竭、脑和/或外周血管疾病、慢性阻塞性肺疾病、射血分数<40%、既往CABG、三支血管和/或左主干病变、纽约心脏协会(NYHA)IV级症状以及紧急或急诊状态。该模型随后的验证显示c统计量为78%。构建了一个在接受CABG的患者中经过内部验证的PrlICULOS风险预测模型。基于术前临床因素,开发了一个记分卡,能够在手术前识别这些患者,并制定旨在优化医院资源的策略。