Strezhneva T Iu, Skorik V I, Safonova E S, Korovkin B F
Vopr Med Khim. 1977 Mar-Apr;23(2):251-4.
A "free" activity of acidic hydrolases (acidic phosphatase, acidic ribonuclease and cathepsin D) was increased in homogenates of dog heart muscle with simultaneous decrease of the enzymes activity in the fraction enriched by lysosomes, within 4-5 hrs after ligation of the descending ramus of sinister mitral artery. The adenylate cyclase activity and content of c-AMP were decreased as compared with unaffected part of myocardium. The data obtained suggest that the decrease of the c-AMP content in the impaired region caused a labilization of lysosomal membranes and the secretion of acidic hydrolases into cell cytoplasm.
在结扎犬左冠状动脉旋支后4 - 5小时内，犬心肌匀浆中酸性水解酶（酸性磷酸酶、酸性核糖核酸酶和组织蛋白酶D）的“游离”活性增加，而溶酶体富集部分的酶活性同时降低。与未受损心肌部分相比，腺苷酸环化酶活性和环磷酸腺苷（c - AMP）含量降低。所获得的数据表明，受损区域c - AMP含量的降低导致溶酶体膜不稳定，并使酸性水解酶分泌到细胞质中。
