Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Respiration. 2010;79(5):383-7. doi: 10.1159/000231975. Epub 2009 Jul 29.
Patients with Mycobacterium avium-intracellulare complex (MAC) pulmonary disease often suffer from weight loss. Adipokines are factors secreted by adipocytes, including leptin and adiponectin, as well as some inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). Body mass index (BMI) is known to be inversely correlated with adiponectin and positively with leptin, TNF-alpha, and IL-6.
We aimed to evaluate the levels of serum adipokines, including adiponectin, leptin, TNF-alpha, and IL-6 in patients with MAC pulmonary disease.
Forty consecutive patients with MAC pulmonary disease (8 males; median age 62 years; median BMI 18.1) were examined. Serum levels of adiponectin, leptin, TNF-alpha, and IL-6 were measured with ELISA. Age-, sex- and BMI-matched healthy subjects served as controls.
Serum adiponectin was significantly elevated in patients with MAC pulmonary disease compared with the controls (p < 0.01). In both the patients and controls, serum adiponectin levels were inversely correlated with BMI (p < 0.05). No significant correlation was observed between serum adiponectin levels and C-reactive protein or lung function. Serum leptin levels, which were positively correlated with BMI, did not differ between patients and controls. Serum levels of TNF-alpha and IL-6 were significantly greater in patients with MAC pulmonary disease than in controls. The levels of TNF-alpha and IL-6 were not correlated with BMI and other adipokines examined.
The results of the present study indicate that, in patients with MAC pulmonary disease, adiponectin is inappropriately secreted and may play a role in the pathophysiology of the disease.
患有鸟分枝杆菌复合群（MAC）肺病的患者常遭受体重减轻。脂联素是脂肪细胞分泌的因素，包括瘦素和脂联素，以及一些炎症细胞因子，肿瘤坏死因子-α（TNF-α）和白细胞介素 6（IL-6）。体重指数（BMI）与脂联素呈负相关，与瘦素、TNF-α和 IL-6呈正相关。
我们旨在评估 MAC 肺病患者的血清脂联素、瘦素、TNF-α和 IL-6 等血清脂联素水平。
检查了 40 例连续 MAC 肺病患者（8 名男性；中位年龄 62 岁；中位 BMI 18.1）。用 ELISA 法测定血清脂联素、瘦素、TNF-α和 IL-6 水平。年龄、性别和 BMI 匹配的健康受试者作为对照组。
与对照组相比，MAC 肺病患者的血清脂联素显著升高（p < 0.01）。在患者和对照组中，血清脂联素水平与 BMI 呈负相关（p < 0.05）。血清脂联素水平与 C 反应蛋白或肺功能无显著相关性。与 BMI 呈正相关的血清瘦素水平在患者和对照组之间无差异。MAC 肺病患者的血清 TNF-α和 IL-6 水平明显高于对照组。TNF-α和 IL-6 水平与 BMI 及其他检测的脂联素无关。
本研究结果表明，在 MAC 肺病患者中，脂联素分泌不当，可能在疾病的病理生理中起作用。
