Soboleva Emma L, Gabbasov Zufar A, Agapov Alexander A, Akchurin Renat S, Saburova Olga S, Romanov Yury A, Smirnov Vladimir N
Cardiology Research Center, Moscow, Russia.
Exp Clin Cardiol. 2005 Fall;10(3):184-8.
Using autopsy specimens and clonal technique, the authors showed that hematopoietic and stromal stem colony-forming units are present in human atheromatous vascular intima. Stromal colony-forming units were also detected in the mononuclear fraction of the blood of patients with hyperlipidemia and coronary stenosis, and were not found in the peripheral blood of normolipidemic volunteers. Using flow cytometry, the absence of stromal circulating colony-forming units in healthy volunteers and their presence in coronary patients was confirmed. It was thought that the presence of circulating stromal precursors with a certain phenotype and variations in their level in blood could serve as an informative noninvasive indicator of coronary stenosis.
通过尸检标本和克隆技术，作者表明造血和基质干细胞集落形成单位存在于人类动脉粥样硬化血管内膜中。在高脂血症和冠状动脉狭窄患者的血液单核细胞部分也检测到了基质集落形成单位，而在血脂正常的志愿者外周血中未发现。使用流式细胞术，证实了健康志愿者中不存在循环基质集落形成单位，而冠状动脉疾病患者中存在。据认为，具有特定表型的循环基质前体细胞的存在及其在血液中的水平变化可作为冠状动脉狭窄的一种有价值的非侵入性指标。
