用于合成对癌细胞具有活性的多功能药物的多组分反应。
Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells.
作者信息
Shabaan Saad, Ba Lalla A, Abbas Muhammad, Burkholz Torsten, Denkert Annika, Gohr André, Wessjohann Ludger A, Sasse Florenz, Weber Wolfgang, Jacob Claus
机构信息
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany.
出版信息
Chem Commun (Camb). 2009 Aug 21(31):4702-4. doi: 10.1039/b823149d. Epub 2009 Jun 22.
DOI:10.1039/b823149d
PMID:19641815
Abstract
Multicomponent Passerini and Ugi reactions enable the fast and efficient synthesis of redox-active multifunctional selenium and tellurium compounds, of which some show considerable cytotoxicity against specific cancer cells.
摘要
多组分Passerini反应和Ugi反应能够快速高效地合成具有氧化还原活性的多功能硒和碲化合物，其中一些化合物对特定癌细胞显示出相当大的细胞毒性。
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