Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, PO Box 151150, D-66123, Saarbruecken, Germany.
Org Biomol Chem. 2009 Nov 21;7(22):4753-62. doi: 10.1039/b907831b. Epub 2009 Sep 11.
Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selectively, appear to kill cancer cells and a range of pathogenic microorganisms. Among the various agents employed, certain redox catalysts have shown considerable promise since they are non-toxic on their own yet develop an effective, often selective cytotoxicity in the presence of the 'correct' intracellular redox partners. Aminoalkylation, amide coupling and multicomponent reactions are suitable synthetic methods to generate a vast number of such multifunctional catalysts, which are chemically diverse and, depending on their structure, exhibit various interesting biological activities.
各种人类疾病，包括多种类型的癌症和传染病，都与细胞氧化还原稳态的变化有关。在过去的十年中，已经探索了几种利用这种失调的氧化还原平衡来治疗疾病的方法。已经开发出能够调节细胞内氧化还原状态的化合物，这些化合物能够有效地、选择性地杀死癌细胞和一系列致病微生物。在使用的各种试剂中，某些氧化还原催化剂显示出相当大的前景，因为它们本身没有毒性，但在存在“正确”的细胞内氧化还原伴侣的情况下会发展出有效的、通常是选择性的细胞毒性。氨基烷基化、酰胺偶联和多组分反应是生成大量此类多功能催化剂的合适合成方法，这些催化剂在化学上具有多样性，并且根据其结构表现出各种有趣的生物活性。
