Shawali Ahmad Sami, Tawfik Nagla M
Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.
Arch Pharm Res. 2009 Jul;32(7):975-82. doi: 10.1007/s12272-009-1701-4. Epub 2009 Jul 31.
Starting from 1-amino-2-methylthio-4-phenylimidazole 2, a series of the title compounds have been synthesized via its reactions with various hydrazonoyl halides 3. The mechanism of the reactions studied is discussed. The structure of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.
从1-氨基-2-甲硫基-4-苯基咪唑2开始，通过它与各种卤代肼叉3反应，合成了一系列标题化合物。讨论了所研究反应的机理。根据元素分析、光谱数据和交替合成对所制备化合物的结构进行了阐明。对所制备化合物的抗菌活性进行了筛选，结果表明大多数此类化合物表现出相当的活性。
