微波辐射下2-芳基-4,5-二（2-噻吩基）咪唑的简便合成及其抗菌活性
A facile synthesis of 2-aryl-4,5-di(2-thienyl)imidazoles under microwave irradiation and their antimicrobial activities.
作者信息
Demirayak S, Mohsen U Abu, Güven K
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu, Eskisehir, Turkey.
出版信息
Boll Chim Farm. 2002 Nov-Dec;141(6):443-6.
PMID:12577514
Abstract
In this study, some 2-aryl-4,5-dithienylimidazoles were synthesized by reacting di-(2-thienyl)ethandione and a suitable aromatic aldehyde in the presence of ammonium acetate in acetic acid. Either the classical reflux method or microwave irradiation method were applied as alternative reaction conditions. The antimicrobial activities of the compounds obtained were investigated in vitro and appreciable activities were obtained.
摘要
在本研究中，通过使二（2-噻吩基）乙二酮与合适的芳香醛在乙酸中乙酸铵存在下反应，合成了一些2-芳基-4,5-二噻吩基咪唑。采用经典回流法或微波辐射法作为替代反应条件。对所得化合物的抗菌活性进行了体外研究，并获得了可观的活性。
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