Division of Psychosocial Research & Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Fam Cancer. 2009;8(4):457-64. doi: 10.1007/s10689-009-9265-5. Epub 2009 Jul 30.
The use of pre-implantation genetic diagnosis (PGD) for hereditary cancer is subject to on-going debate, particularly among professionals. This study evaluates the attitude towards PGD and attitude-associated characteristics of those concerned: family members with a hereditary cancer predisposition. Forty-eight Von Hippel-Lindau and 18 Li-Fraumeni Syndrome families were identified via the 9 family cancer clinics in the Netherlands. In total, 216 high risk family members and partners were approached, of whom 179 (83%) completed a self-report questionnaire. Of the high risk family members, 35% expressed a positive attitude towards PGD. Those with a current desire to have children were significantly more likely to have a positive attitude: 48% would consider the use of PGD. No other sociodemographic, medical or psychosocial variables were associated significantly with a positive attitude. The most frequently reported advantage of PGD is the avoidance of a possible pregnancy termination. Uncertainty about late effects was the most frequently reported disadvantage. These results indicate that approximately half of those contemplating a future pregnancy would consider the use of PGD. The actual uptake, however, is expected to be lower. There is no indication that psychosocial factors affect interest in PGD.
使用植入前遗传学诊断（PGD）来治疗遗传性癌症一直存在争议，尤其是在专业人士中。本研究评估了那些有遗传癌症易感性的家庭成员对 PGD 的态度及其相关特征。通过荷兰的 9 家家族癌症诊所，确定了 48 个 Von Hippel-Lindau 和 18 个 Li-Fraumeni 综合征家族。总共联系了 216 名高危家族成员及其伴侣，其中 179 名（83%）完成了一份自我报告问卷。在高危家族成员中，35%对 PGD 持积极态度。目前有生育愿望的人更有可能持积极态度：48%会考虑使用 PGD。其他社会人口统计学、医学或心理社会变量与积极态度没有显著关联。PGD 最常被报道的优势是避免可能的妊娠终止。不确定性是最常被报道的缺点。这些结果表明，大约一半考虑未来怀孕的人会考虑使用 PGD。然而，实际的使用量预计会更低。没有迹象表明心理社会因素会影响对 PGD 的兴趣。
