神经内分泌肿瘤中神经元特异性烯醇化酶、突触素、嗜铬粒蛋白及内分泌颗粒成分的免疫组化鉴定
Immunohistochemical identification of neuron-specific enolase, synaptophysin, chromogranin and endocrine granule constituent in neuroendocrine tumours.
作者信息
Vyberg M, Horn T, Francis D, Askaa J
机构信息
Department of Pathology, Hvidovre Hospital, Denmark.
出版信息
Acta Histochem Suppl. 1990;38:179-81.
Immunohistochemical identification of neuroendocrine tumour markers in paraffin embedded material from 22 tumours (5 small cell carcinomas of the lung (SCCL), 12 carcinoids, 2 medullary thyroid carcinomas, 2 pheochromocytomas and one paraganglioma) with electron microscopically verified dense-core granules revealed neuron-specific enolase in all but one tumour, synaptophsin in 15/22 (2 SCCL and 6 carcinoids negative), chromogranin in 16/22 (all SCCL and one carcinoid negative), and endocrine granule constituent in 18/22 (4 SCCL negative). The Grimelius silver methods stained 13/22 (all cases of SCCL and 4 carcinoids negative).
对22个肿瘤（5例肺小细胞癌（SCCL）、12例类癌、2例甲状腺髓样癌、2例嗜铬细胞瘤和1例副神经节瘤）石蜡包埋材料中的神经内分泌肿瘤标志物进行免疫组织化学鉴定，这些肿瘤经电子显微镜证实存在致密核心颗粒。结果显示，除1个肿瘤外，其余肿瘤均检测到神经元特异性烯醇化酶；15/22个肿瘤检测到突触素（2例SCCL和6例类癌阴性）；16/22个肿瘤检测到嗜铬粒蛋白（所有SCCL和1例类癌阴性）；18/22个肿瘤检测到内分泌颗粒成分（4例SCCL阴性）。Grimelius银染法在13/22个肿瘤中呈阳性（所有SCCL病例和4例类癌阴性）。
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