Schürmann G, Betzler M, Buhr H J
Department of Surgery, University of Heidelberg, FRG.
Eur J Surg Oncol. 1990 Aug;16(4):298-303.
Neuroendocrine (NE) tumours of the gastro-entero-pancreatic tract were analysed immunohistochemically for the expression of chromogranin A, neuron-specific enolase and synaptophysin. In all cases at least one marker was present and in 17 out of 19 investigated neoplasms, at least one of the three markers could be demonstrated in more than 75% of the NE tumour cells. Monoclonal antibody chromogranin A stained a much higher proportion of NE cells in tumours with hormonal activity than in hormonally inactive ones. Immunostaining of the primary tumour as compared to its respective metastases was almost identical. Thus, chromogranin A, neuron-specific enolase and synaptophysin identify NE tumours and their metastases regardless of their localization and their state of hormonal activity. As 'panendocrine' markers of NE tumours they are of special diagnostic value in NE tumours that do not produce hormones and peptides.
对胃肠道胰腺神经内分泌（NE）肿瘤进行免疫组织化学分析，以检测嗜铬粒蛋白A、神经元特异性烯醇化酶和突触素的表达。在所有病例中，至少有一种标志物存在，在19个被研究的肿瘤中，有17个肿瘤的三种标志物中至少有一种在超过75%的NE肿瘤细胞中可被检测到。与无激素活性的肿瘤相比，单克隆抗体嗜铬粒蛋白A在有激素活性的肿瘤中染色的NE细胞比例要高得多。与各自的转移灶相比，原发肿瘤的免疫染色几乎相同。因此，嗜铬粒蛋白A、神经元特异性烯醇化酶和突触素可识别NE肿瘤及其转移灶，无论其定位和激素活性状态如何。作为NE肿瘤的“泛内分泌”标志物，它们在不产生激素和肽的NE肿瘤中具有特殊的诊断价值。
