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[大鼠旷场行为指标以及循环骤停后中枢神经系统的存活和功能恢复特征]

[The indices of rat open-field behavior and the characteristics of the survival and functional recovery of the CNS following circulatory arrest].

作者信息

Mutuskina E A, Nezlina N I, Kulikov M A, Gurvich A M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Sep-Oct;40(5):988-94.

PMID:1964347
Abstract

In experiments on rats it has been shown that for prognostication of successful reanimation after the clinic death of different duration (5, 10, 15 min) correlative interactions between the parameters of behaviour in the open field before blood circulation cessation are more essential than their absolute values. Highly significant correlation coefficients (0.7 and more) between the majority of behaviour parameters were typical for the group of animals which had survived after a prolonged blood circulation cessation (15 min); for rats rehabilitated after 5- and 10-min cessation of the blood circulation--between the characteristics reflecting, basically, the motor-investigating component of the behaviour. In groups of died animals (independently on the duration of clinic death) correlation profile was restricted to characteristics determining only the character of the motor activity. Particular significance is underlined of emotionally psychic components of the behaviour for complete CNS restoration after a prolonged blood circulation cessation in comparison with the shorter ones.

摘要

在对大鼠的实验中已经表明,对于不同时长(5分钟、10分钟、15分钟)临床死亡后成功复苏的预后判断,血液循环停止前在旷场试验中的行为参数之间的相关性相互作用比其绝对值更为重要。在血液循环长时间停止(15分钟)后存活的动物组中,大多数行为参数之间具有高度显著的相关系数(0.7及以上);对于在血液循环停止5分钟和10分钟后恢复的大鼠,相关性主要存在于基本反映行为的运动探索成分的特征之间。在死亡动物组中(与临床死亡时长无关),相关情况仅限于仅决定运动活动特征的参数。与较短时长的临床死亡相比,行为的情绪心理成分对于长时间血液循环停止后中枢神经系统的完全恢复具有特别重要的意义。

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