Jin L
Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1990 Dec;19(4):288-90.
Detection of HBxAg was done by the immunogold-silver staining technique in 22 liver cancer specimens from patients with hepatocellular carcinoma and positive markers of hepatitis B were found to express HBxAg of hepatitis B virus, which was distributed in the perinuclear cytoplasm. The result suggests that HBxAg can be detected practically in all the liver specimens of the patients with hepatocellular carcinoma, who had been infected by hepatitis B virus. The relationship between X gene and its translation product and hepatocellular carcinoma is discussed.
采用免疫金银染色技术对22例肝细胞癌患者的肝癌标本进行HBxAg检测，发现乙肝阳性标志物表达乙肝病毒的HBxAg，其分布于核周细胞质中。结果表明，在所有感染过乙肝病毒的肝细胞癌患者的肝脏标本中均可实际检测到HBxAg。文中讨论了X基因及其翻译产物与肝细胞癌之间的关系。
