Wawrzynowicz-Syczewska Marta, Karpińska Ewa, Jurczyk Krzysztof, Laurans Lukasz, Boroń-Kaczmarska Anna
Department of Infectious Diseases and Hepatology, Pomeranian Medical University, Szczecin, Poland.
Ann Transplant. 2009 Jul-Sep;14(3):45-50.
Weight gain is commonly observed after OLTx. It is still debatable whether increasing weight is due to the regain of weight lost before transplantation or it is a complex metabolic disorder.
MATERIAL/METHODS: Body mass index and weight gain were sought at 6 months, one, two and four years after liver transplantation (OLTx) in relation to sex, weight at the time of transplantation, aetiology of liver disease, type of immunosuppression, glucose metabolism and lipid parameters as well as cardiovascular episodes. A group of 75 patients has been studied.
Mean weight gain and BMI change were the highest within the first six months after OLTx (6.1 kg and 2.0 kg/m(2), respectively); since than gaining weight decreased. Men gained more weight than women, especially in the first half-year after OLTx. The only clear predictive factor of overweight and obesity was the baseline weight (the higher the baseline weight the most dynamic the weight gain after OLTx).
Dietary mistakes and lack of physical activity may play a major role in the weight increase after OLTx. Despite striking proportion of overweight and obese patients in the studied group, the number of cardiovascular episodes seem to match the general population.
肝移植术后体重增加是常见现象。体重增加是由于移植前丢失体重的恢复，还是一种复杂的代谢紊乱，目前仍存在争议。
材料/方法：在肝移植（OLTx）后6个月、1年、2年和4年时，研究体重指数和体重增加情况，涉及性别、移植时体重、肝病病因、免疫抑制类型、糖代谢和脂质参数以及心血管事件。共研究了75例患者。
肝移植术后前6个月平均体重增加和BMI变化最高（分别为6.1 kg和2.0 kg/m²）；此后体重增加减少。男性比女性体重增加更多，尤其是在肝移植术后的前半年。超重和肥胖的唯一明确预测因素是基线体重（基线体重越高，肝移植术后体重增加越显著）。
饮食错误和缺乏体育活动可能在肝移植术后体重增加中起主要作用。尽管研究组中超重和肥胖患者比例惊人，但心血管事件的数量似乎与普通人群相当。
