Skin and Allergy Hospital, Finland.
J Pediatr Gastroenterol Nutr. 2009 Nov;49(5):626-30. doi: 10.1097/MPG.0b013e31819de849.
: Regarding safety, we investigated the effect of prenatal probiotic and 6 months of pro- and prebiotic supplementation of infants on their hematologic values at 6 months and 2 years and factors affecting these values.
: In a prospective randomized controlled probiotic intervention trial in infants at high risk for allergy, we obtained blood samples consecutively from 98 infants at 6 months and from 658 children at 2 years to measure hematologic values. We collected fecal samples at 3 and 6 months to measure immunologic development by calprotectin, alpha-1-antitrypsin, tumor necrosis factor-alpha, and immunoglobulin A.
: At 6 months, infants in the probiotic group had significantly lower hemoglobin (Hb) values than did the placebo group, mean (SD): 119.8 g/L (6.3) versus 123.3 g/L (8.4), P = 0.025. Adjustment for factors that might affect Hb values (breast-feeding duration, solid-food introduction, and sex), revealed no need for adjustment. A significant negative correlation emerged between Hb values at 6 months and fecal calprotectin at age 3 months r = -0.301, P = 0.009, which was affected neither by breast-feeding, sex, nor study group. At 2 years, hematologic values in both groups became similar.
: Probiotics cause a gut mucosal inflammation with decreased Hb values during intervention, corrected after halting the supplementation.
关于安全性，我们研究了产前益生菌和婴儿 6 个月的 pro- 和 prebiotic 补充对他们 6 个月和 2 岁时血液值的影响，以及影响这些值的因素。
在一项针对过敏高风险婴儿的前瞻性随机对照益生菌干预试验中，我们连续从 98 名 6 个月大的婴儿和 658 名 2 岁的儿童中采集血液样本，以测量血液值。我们在 3 个月和 6 个月时采集粪便样本，以通过钙卫蛋白、α-1-抗胰蛋白酶、肿瘤坏死因子-α和免疫球蛋白 A 来测量免疫发育。
在 6 个月时，益生菌组婴儿的血红蛋白（Hb）值明显低于安慰剂组，平均值（标准差）：119.8 g/L（6.3）与 123.3 g/L（8.4），P = 0.025。调整可能影响 Hb 值的因素（母乳喂养持续时间、固体食物引入和性别），无需调整。在 3 个月龄时粪便钙卫蛋白与 6 个月时 Hb 值之间出现显著负相关 r = -0.301，P = 0.009，这不受母乳喂养、性别或研究组的影响。在 2 岁时，两组的血液值变得相似。
益生菌会引起肠道黏膜炎症，导致干预期间 Hb 值下降，停止补充后得到纠正。
