Helaly Soleiman, Schneider Kathrin, Nachtigall Jonny, Vikineswary Sabaratnam, Tan Geok Yuan Annie, Zinecker Heidi, Imhoff Johannes F, Süssmuth Roderich D, Fiedler Hans-Peter
Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
J Antibiot (Tokyo). 2009 Aug;62(8):445-52. doi: 10.1038/ja.2009.70. Epub 2009 Jul 31.
Gombapyrones A-D, new members of the alpha-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3beta.
冈巴吡喃酮A - D是次生代谢产物α-吡喃酮家族的新成员，由从竹根际分离出的灰色链霉菌Acta 3662产生。该菌株通过其形态学和化学分类学特征以及16S rDNA测序鉴定为灰色链霉菌。冈巴吡喃酮的结构通过质谱和核磁共振实验确定，发现它们对蛋白酪氨酸磷酸酶1B和糖原合酶激酶3β具有抑制活性。
