Wilkins Benjamin J, Lewis James S
Head and Neck Pathology Section, Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., P.O. Box 8118, St. Louis, MO 63110-1093, USA.
Head Neck Pathol. 2009 Jun;3(2):140-9. doi: 10.1007/s12105-009-0115-4. Epub 2009 Apr 28.
Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5-2% of cases of primary hyperparathyroidism. Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature. Importantly, margin status at resection is related to prognosis, and only a handful of case reports of non-functional carcinoma note this important parameter. Here we report the first case of non-functional parathyroid carcinoma with negative margins, and review the literature on this rare entity. Whether functional or non-functional, parathyroid carcinoma can often be difficult to differentiate from benign parathyroid adenoma. While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors.
甲状旁腺癌是一种罕见的恶性肿瘤，仅占原发性甲状旁腺功能亢进病例的0.5%-2%。不到10%的甲状旁腺癌无功能，因此，文献中对此类病例的报道很少。重要的是，手术切缘状态与预后相关，而关于无功能癌的病例报告中仅有少数提及这一重要参数。在此，我们报告首例切缘阴性的无功能甲状旁腺癌病例，并回顾有关这一罕见实体的文献。无论有无功能，甲状旁腺癌通常都很难与良性甲状旁腺腺瘤相鉴别。虽然诊断一直基于临床和组织学标准，但有关甲状旁腺癌分子基础的最新数据可能有助于提高鉴别良性和恶性甲状旁腺肿瘤的准确性。
