Teichtahl Andrew J, Wluka Anita E, Forbes Andrew, Wang Yuanyuan, English Dallas R, Giles Graham G, Cicuttini Flavia M
Monash University and Alfred Hospital, Melbourne, Victoria, Australia.
Arthritis Rheum. 2009 Aug 15;61(8):1095-102. doi: 10.1002/art.24840.
There are few data concerning possible long-term effects of physical activity on cartilage change in the patellofemoral compartment. We examined the effect of participation in vigorous physical activity on changes to patella cartilage over 2 years.
A total of 297 healthy adults ages 50-79 years with no history of knee injury or symptoms were recruited from an existing study. Physical activity data were obtained by questionnaire at baseline (2003-2004). Patella cartilage volume and defects were determined by magnetic resonance imaging at baseline (2003-2004) and followup (2006-2007).
Participation in vigorous physical activity at baseline was associated with a reduced rate of patella cartilage volume loss (-21.2 mm(3) per annum [95% confidence interval (95% CI) -41.5, -1.0; P = 0.04]) and a trend toward less risk of worsening patella cartilage defects (odds ratio 0.4; 95% CI 0.2, 1.1 [P = 0.07]) over the subsequent 2 years. In the subgroup with no significant patella cartilage defects at baseline (n = 192), participation in vigorous physical activity was associated with a reduced annual rate of patella cartilage volume loss (95% CI -53.8, -7.8; P = 0.03) and a trend for fewer new patella cartilage defects (95% CI 0.1, 1.1; P = 0.08). No significant relationships were found between vigorous physical activity and cartilage volume change or defect progression in the subgroup with prevalent patella cartilage defects at baseline.
These observations suggest that vigorous physical activity is beneficial to patellofemoral joints for people without preexisting cartilage damage. Weight-bearing vigorous physical activity might, therefore, be useful in the prevention of patellofemoral osteoarthritis.
关于体力活动对髌股关节软骨变化可能产生的长期影响的数据较少。我们研究了参与剧烈体力活动对2年期间髌骨软骨变化的影响。
从一项现有研究中招募了297名年龄在50 - 79岁之间、无膝关节损伤或症状病史的健康成年人。在基线期（2003 - 2004年）通过问卷调查获取体力活动数据。在基线期（2003 - 2004年）和随访期（2006 - 2007年）通过磁共振成像确定髌骨软骨体积和缺损情况。
基线期参与剧烈体力活动与髌骨软骨体积减少率降低相关（每年减少21.2立方毫米[95%置信区间（95%CI）-41.5，-1.0；P = 0.04]），并且在随后2年中髌骨软骨缺损恶化风险有降低趋势（优势比0.4；95%CI 0.2，1.1[P = 0.07]）。在基线期无明显髌骨软骨缺损的亚组（n = 192）中，参与剧烈体力活动与髌骨软骨体积年减少率降低相关（95%CI -53.8，-7.8；P = 0.03），且有新的髌骨软骨缺损减少的趋势（95%CI 0.1，1.1；P = 0.08）。在基线期有髌骨软骨缺损的亚组中，未发现剧烈体力活动与软骨体积变化或缺损进展之间存在显著关系。
这些观察结果表明，对于没有先前软骨损伤的人来说，剧烈体力活动对髌股关节有益。因此，负重剧烈体力活动可能有助于预防髌股关节骨关节炎。
