Yonkov D I, Georgiev V P
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Neuropeptides. 1990 Jul;16(3):157-62. doi: 10.1016/0143-4179(90)90128-l.
The influence of the cholinesterase inhibitor galanthamine (Nivalin), of the cholinergic agonist oxotremorine, and of the muscarinic cholinergic antagonist scopolamine on the retention-improving effect of angiotensin II (AT II) was studied in male Wistar rats trained and tested for retention (24h later) using two paradigms: two-way active avoidance (shuttle-box) and passive (step-through) avoidance. AT II and the cholinergic agonists, administered together potentiated their retention-improving effects, while scopolamine abolished the memory effect of AT II. It is suggested that brain cholinergic neurotransmission participates in the mechanisms of the memory-facilitating effect of AT II.
在雄性Wistar大鼠中，使用双向主动回避（穿梭箱）和被动（一步通过）回避两种范式，研究了胆碱酯酶抑制剂加兰他敏（尼瓦林）、胆碱能激动剂氧化震颤素和毒蕈碱胆碱能拮抗剂东莨菪碱对血管紧张素II（AT II）改善记忆效果的影响。在训练和测试记忆（24小时后）时，将AT II与胆碱能激动剂一起给药可增强它们改善记忆的效果，而东莨菪碱则消除了AT II的记忆效应。提示脑胆碱能神经传递参与了AT II促进记忆作用的机制。
