Georgiev V, Yonkov D
Methods Find Exp Clin Pharmacol. 1985 Aug;7(8):415-8.
The effects of the octapeptide angiotensin II (AT II) on acquisition and retention in active avoidance tasks in shuttle-box-trained rats were studied. AT II at doses of 0.1, 0.5 and 1 microgram administered intracerebroventricularly (i.c.v.) 15 min before training facilitated learning and retention. AT II injected immediately after training also improved retention when tests were given 24 h post-trial. Saralasin at a dose of 1 microgram i.c.v. administered 15 min before training did not influence acquisition but antagonized the learning-facilitating effect of AT II. Saralasin at a dose of 5 micrograms injected immediately after training improved retention but abolished the retention-facilitating effect of AT II. It is suggested that the AT II effects on memory processes in active avoidance tasks are realized through specific angiotensin receptors in the brain structures.
研究了八肽血管紧张素II（AT II）对穿梭箱训练大鼠主动回避任务中习得和记忆保持的影响。在训练前15分钟脑室内注射（i.c.v.）剂量为0.1、0.5和1微克的AT II可促进学习和记忆保持。在试验后24小时进行测试时，训练后立即注射AT II也可改善记忆保持。在训练前15分钟脑室内注射剂量为1微克的沙拉新不影响习得，但拮抗了AT II的学习促进作用。训练后立即注射剂量为5微克的沙拉新可改善记忆保持，但消除了AT II的记忆保持促进作用。提示AT II对主动回避任务中记忆过程的影响是通过脑结构中的特定血管紧张素受体实现的。
