Yan Qiao-Na, Zhang Shuo, Zhang Zhen-Qiu
Pharmacy College, Liaoning University of TCM, Dalian 116600, China.
Zhong Yao Cai. 2009 Apr;32(4):575-8.
To study the effects of Rhizoma Coptidis extracts and Rhizoma Coptidis and Cortex Cinnamomi extracts on the distribution of terberine in rats' tissues.
The rats were intragastrically given the two different extracts. HPLC was used to determine the concentration of berberine in rats' tissues and the sample was extracted by liquid-liquid extraction method.
At the same time, with the same gavage of the three extracts, the trend of the berberine in rats was: the concentration of Rhizoma Coptidis and Cortex Cinnamomi extracts > the concentration of Rhizoma Coptidis extracts.
Berberine can be detected in intestinal, stomach, colon, pancreatic, heart, kidney, liver, spleen, lung, testicular, uterus, especially the gastrointestinal system with higher concentration, so berberine has a wide range of distribution in vivo.
研究黄连提取物及黄连肉桂提取物对大鼠组织中黄连素分布的影响。
给大鼠灌胃两种不同提取物。采用高效液相色谱法测定大鼠组织中黄连素的浓度，样品采用液液萃取法提取。
同时，给予三种提取物相同灌胃量时，大鼠体内黄连素的趋势为：黄连肉桂提取物浓度＞黄连提取物浓度。
在肠道、胃、结肠、胰腺、心脏、肾脏、肝脏、脾脏、肺、睾丸、子宫中均可检测到黄连素，尤其是在胃肠道系统中浓度较高，因此黄连素在体内分布广泛。
