Wang Xiao-qiang, Yang Ming-wei, Liu Fang-fang, Lu Fu-er, Xu Li-jun, Zou Xin
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhongguo Zhong Yao Za Zhi. 2007 Sep;32(17):1795-7.
To study the effect of Rhizoma Coptidis and Radix Rehmanniae with the different ratio on the pharmacokinetics of berberine in rats.
24 rats were grouped to 4 groups randomly. Decoction, in which the proportion of Rhizoma Coptidis to Radix Rehmanniae is 1:0, 1:1, 1:4, 1:8 differently, was intragastrically given to the 4 groups. HPLC was used to determine concentration of berberine in serum. We adopted DAS 2.0 to analysis pharmacokinetic parameters of berberine.
The concentration-time curves was all fitted to two-compartment model with a weight of 1/C2. Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05).
Radix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats.
研究不同配比黄连与地黄对大鼠体内小檗碱药代动力学的影响。
将24只大鼠随机分为4组，分别给予黄连与地黄比例为1:0、1:1、1:4、1:8的水煎液灌胃，采用高效液相色谱法测定血清中小檗碱的浓度，运用DAS 2.0软件分析小檗碱的药代动力学参数。
血药浓度-时间曲线均符合权重为1/C2的二室模型，4组的C(max)、AUC(0-t)、AUC(0-∞)差异有统计学意义（P<0.05）。
大剂量地黄可有效提高大鼠体内小檗碱的生物利用度。
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