黄连与肉桂共给药对大鼠体内小檗碱组织分布的影响
[Effect of Rhizoma Coptidis coadministration with Cortex Cinnamomi on tissue distribution of berberine in rats].
作者信息
Zhang Rui, Li Kaipeng, Yang Jie, Huang Guo, Yang Lijuan, Zhang Yujie
机构信息
School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2180-3.
OBJECTIVE
To investigate the tissue distribution of berberine in rats after oral administration of Rhizoma Coptidis with Cortex Cinnamomi powder.
METHOD
After oral administration of Rhizoma Coptidis powder and Rhizoma Coptidis with Cortex Cinnamomi powder (6:1) at the dosage of 6 g x kg(-1) and 6.6 g x kg(-1) respectively per day for 1 week, the drug concentrations in various tissues were determined by HPLC method. The variations of berberine concentrations in tissues of two treated group of rats were compared by t test using software of SAS.
RESULT
With repeated administration of Rhizoma Coptidis powder, berberine distributed widely in tissues of rats and the concentrations of berberine in tissues increased, yet berberine existed mainly in liver. Berberine concentrations in all organs investigated in the group of rats treated with Rhizoma Coptidis and Cortex Cinnamomi powder showed obvious difference with those of the group of rats treated with Rhizoma Coptidis powder (P < 0.01). The berberine concentrations increased in heart, liver and kidney, while decreased in spleen and lung.
CONCLUSION
Rhizoma Coptidis coadministration with Cortex Cinnamomi can obviously change the distribution of berberine in rat organs.
目的
研究大鼠口服黄连肉桂粉后小檗碱在体内的组织分布情况。
方法
分别以6 g·kg⁻¹和6.6 g·kg⁻¹的剂量每日给大鼠灌胃黄连粉和黄连肉桂粉（6∶1），连续1周，采用高效液相色谱法测定各组织中的药物浓度。使用SAS软件通过t检验比较两组处理大鼠组织中小檗碱浓度的变化。
结果
重复灌胃黄连粉后，小檗碱在大鼠组织中广泛分布，组织中的小檗碱浓度升高，但小檗碱主要存在于肝脏。黄连肉桂粉处理组大鼠所有检测器官中的小檗碱浓度与黄连粉处理组相比均有显著差异（P < 0.01）。心脏、肝脏和肾脏中的小檗碱浓度升高，而脾脏和肺中的小檗碱浓度降低。
结论
黄连与肉桂合用可明显改变小檗碱在大鼠器官中的分布。
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