钯直接催化芳基溴化物与2/9-取代嘧啶并[5,4-b]中氮茚的芳基化反应。

Direct palladium-catalyzed arylations of aryl bromides with 2/9-substituted pyrimido[5,4-b]indolizines.

作者信息

Jiang Min, Li Ting, Meng Linghua, Yang Chunhao, Xie Yuyuan, Ding Jian

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 PR China.

出版信息

J Comb Chem. 2009 Sep-Oct;11(5):806-8. doi: 10.1021/cc800162k.

DOI:10.1021/cc800162k

PMID:19645499

Abstract

C-5 arylated 2/9-substituted pyrimido[5,4-b]indolizines were synthesized via palladium-catalyzed direct arylation. A variety of substituents on both pyrimido[5,4-b]indolizines and aryl/heteroaryl bromides are tolerated, providing rapid access to substituted pyrimido[5,4-b]indolizines in good to excellent yields.

摘要

通过钯催化的直接芳基化反应合成了C-5芳基化的2/9-取代嘧啶并[5,4-b]中氮茚。嘧啶并[5,4-b]中氮茚和芳基/杂芳基溴化物上的各种取代基都能被耐受，从而能够以良好至优异的产率快速获得取代的嘧啶并[5,4-b]中氮茚。