Rajneesh Kiran F, Binder Devin K
Department of Neurological Surgery, University of California, Irvine, California, USA.
Neurosurg Focus. 2009 Aug;27(2):E4. doi: 10.3171/2009.5.FOCUS09101.
Tumor-associated epilepsy is an important contributor to morbidity in patients with brain tumors. Proposed pathophysiological mechanisms to explain these effects range from neuronal and glial dysfunction to deranged vascular homeostasis, to ionic and pH changes. Perilesional tissue alterations play a vital role in the generation of tumor-associated seizures. Clinical studies have determined that tumor-associated seizures are usually focal with secondary generalization and often resistant to antiepileptic drugs. Tumor histopathological characteristics and location are independent factors that impact seizure burden. Further understanding of the mechanisms of tumor-associated epilepsy may lead to new types of treatments targeted at perilesional tissue alterations.
肿瘤相关性癫痫是脑肿瘤患者发病的重要因素。用于解释这些影响的病理生理机制范围广泛，从神经元和胶质细胞功能障碍到血管稳态紊乱，再到离子和pH值变化。瘤周组织改变在肿瘤相关性癫痫发作的产生中起着至关重要的作用。临床研究已确定，肿瘤相关性癫痫发作通常为局灶性发作继发全身性发作，且往往对抗癫痫药物耐药。肿瘤的组织病理学特征和位置是影响癫痫发作负担的独立因素。对肿瘤相关性癫痫机制的进一步了解可能会带来针对瘤周组织改变的新型治疗方法。
