[非诺匹定对豚鼠离体心脏收缩-舒张过程中环磷酸腺苷动力学的作用]
[The action of fenoptin on cAMP dynamics in the isolated guinea pig heart during contraction-relaxation].
作者信息
Laptev B I, Bardamova I B, Afanas'ev S A, Talaeva E Iu
出版信息
Biull Eksp Biol Med. 1990 Nov;110(11):455-7.
PMID:1964602
Abstract
The influence of finoptin and Ca2+ concentration decrease on cAMP dynamic during cardiac cycle in guinea pig isolated heart, activated by isadrin (3 x 10(-8) M), has been studied. In isadrin activation of adrenoceptors cAMP concentration increased by 50% during contraction and decreased during relaxation. Hypocalcium solution (0.15 mM) and finoptin decreased cAMP concentration and influenced its dynamic during cardiac cycle.
摘要
研究了豚鼠离体心脏在异肾上腺素（3×10⁻⁸ M）激活下，氟哌啶醇和Ca²⁺浓度降低对心动周期中cAMP动态变化的影响。在异肾上腺素激活肾上腺素能受体时，收缩期cAMP浓度增加50%，舒张期降低。低钙溶液（0.15 mM）和氟哌啶醇降低了cAMP浓度，并影响其在心动周期中的动态变化。
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