Schwab C R, Mote B E, Du Z-Q, Amoako R, Baas T J, Rothschild M F
National Swine Registry, West Lafayette, Indiana, USA.
J Anim Breed Genet. 2009 Jun;126(3):228-36. doi: 10.1111/j.1439-0388.2008.00770.x.
A sufficient level of intramuscular fat (IMF) is needed to enhance consumer acceptance of pork products, and is currently receiving greater attention within swine genetic improvement programmes. An examination of previously described and novel genetic variants within candidate genes for IMF deposition was performed to evaluate potential use of genetic markers in marker-assisted selection (MAS). Biological candidate genes implicated to play a role in adipogenesis were investigated within two different lines of purebred Duroc pigs. These included MC4R, FABP3, DLK1, and TCF7L2. Significant variation in IMF within the control line was described by the MC4R genotype and a novel BsrfI single nucleotide polymorphism within the FABP3 gene. Genetic markers for DLK1 and TCF7L2 evaluated in this population are not currently recommended for selection in Duroc swine. Existence of MC4R and FABP3 mutations may be useful markers in MAS aimed at IMF improvement, provided that gene effects are segregating and the presence of an association is detected within the population. However, additional work to confirm the use of the investigated genetic markers in selection programmes is needed.
需要有足够水平的肌内脂肪（IMF）来提高消费者对猪肉产品的接受度，目前在猪遗传改良计划中受到了更多关注。对先前描述的以及与IMF沉积相关的候选基因中的新遗传变异进行了检测，以评估遗传标记在标记辅助选择（MAS）中的潜在用途。在两个不同品系的纯种杜洛克猪中研究了与脂肪生成相关的生物学候选基因。这些基因包括黑素皮质素4受体（MC4R）、脂肪酸结合蛋白3（FABP3）、Delta样蛋白1（DLK1）和转录因子7样蛋白2（TCF7L2）。MC4R基因型以及FABP3基因内一个新的BsrFI单核苷酸多态性描述了对照品系中IMF的显著差异。目前不建议在该群体中选择用于评估DLK1和TCF7L2的遗传标记。如果基因效应能够分离并且在群体中检测到关联，MC4R和FABP3突变的存在可能是旨在改善IMF的MAS中的有用标记。然而，需要开展更多工作来确认所研究的遗传标记在选择计划中的用途。
