Alpert Medical School at Brown University, Providence, RI, USA.
Epidemiol Infect. 2010 Mar;138(3):313-7. doi: 10.1017/S0950268809990483. Epub 2009 Aug 3.
We utilized Medline to perform a systematic review of the literature to quantify the aetiology of cellulitis with intact skin. Of 808 patients with cellulitis, 127-129 (15.7-16.0%) patients had positive needle aspiration and/or punch biopsy cultures from intact skin. Of the patients with positive cultures, 65 (50.4-51.2%) had cultures positive for Staphylococcus aureus, 35 (27.1-27.6%) for group A streptococcus, and 35-37 (27.1-29.1%) for other pathogens. The most common aetiology of cellulitis with intact skin, when it can be determined, is S. aureus, outnumbering group A streptococcus by a ratio of nearly 2:1. Given the increasing incidence of community-associated methicillin-resistant S. aureus infections, our findings may have critical therapeutic implications.
我们利用 Medline 进行了系统的文献回顾，以量化完整皮肤蜂窝织炎的病因。在 808 例蜂窝织炎患者中，127-129（15.7-16.0%）例患者的完整皮肤经针吸和/或切取活检培养阳性。在培养阳性的患者中，65 例（50.4-51.2%）培养出金黄色葡萄球菌，35 例（27.1-27.6%）为 A 组链球菌，35-37 例（27.1-29.1%）为其他病原体。当可以确定完整皮肤蜂窝织炎的病因时，最常见的病因是金黄色葡萄球菌，其与 A 组链球菌的比例接近 2:1。鉴于社区相关性耐甲氧西林金黄色葡萄球菌感染的发病率不断增加，我们的研究结果可能具有重要的治疗意义。
