Liu Jilun, Li Shuning, Yang Wei, Fan Xuhui
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Medicine (Baltimore). 2025 Jun 27;104(26):e42978. doi: 10.1097/MD.0000000000042978.
Odontogenic infections are a major contributor to the occurrence of maxillofacial space infections (MSI) worldwide. Despite effective management, MSI can lead to severe complications. This study aimed to identify patient characteristics, treatment strategies, and outcomes associated with MSI in a specialized healthcare setting, focusing on risk factors for life-threatening complications. In this case-control study, we analyzed 116 medical records and surveyed 116 healthy individuals. Data collected included gender, age, body mass index (BMI), presence of diabetes, hypertension, coronary artery disease, cohabitation status with children or parents, and educational level. For patients with MSI, clinical symptoms, treatment courses, and hospitalization duration were documented. Patients with MSI were predominantly aged 50 to 70 and had higher BMIs (P < .05), with 57.76% being male. Only 33.62% of these patients cohabited with children or parents (P < .01), and many had lower educational levels (P < .01). Higher BMI, solitary living (not cohabiting with children or parents), and lower educational levels independently increased the risk of MSI. The influence of the home environment on MSI warrants further attention.
牙源性感染是全球范围内颌面部间隙感染（MSI）发生的主要原因。尽管有有效的治疗方法，但MSI仍可能导致严重并发症。本研究旨在确定在专业医疗环境中与MSI相关的患者特征、治疗策略和结局，重点关注危及生命并发症的危险因素。在这项病例对照研究中，我们分析了116份病历，并对116名健康个体进行了调查。收集的数据包括性别、年龄、体重指数（BMI）、糖尿病、高血压、冠状动脉疾病的患病情况、与子女或父母的同居状况以及教育程度。对于患有MSI的患者，记录了临床症状、治疗疗程和住院时间。患有MSI的患者主要年龄在50至70岁之间，BMI较高（P < 0.05），其中57.76%为男性。这些患者中只有33.62%与子女或父母同居（P < 0.01），而且许多人教育程度较低（P < 0.01）。较高的BMI、独居（不与子女或父母同居）和较低的教育程度独立增加了MSI的风险。家庭环境对MSI的影响值得进一步关注。
