de Bruïne J F, Limburg M, van Royen E A, Hijdra A, Hill T C, van der Schoot J B
Department of Nuclear Medicine, Academisch Medisch Centrum, Amsterdam, The Netherlands.
Eur J Nucl Med. 1990;17(5):248-51. doi: 10.1007/BF00812365.
Thirty-five patients with acute ischaemic stroke were studied within 24 h after hospital admission with thallium 201 diethyldithiocarbamate single photon emission tomography (201Tl-DDC SPET) and X-ray computed tomography (CT). 201Tl-DDC is a non-redistributing agent that allows postponed imaging after early administration and early therapeutic intervention. In 16 patients both investigations were performed within 24 h after stroke onset. The sensitivity of SPET was 94% and of CT 81% in the first 24 h, when hypodensity and obliteration of sulci were used as CT reading criteria. When only hypodensity was used as a criterion, the sensitivity of CT was 50% in this group. Sensitivity of CT compared with SPET became increasingly better in patients with older infarcts (1-18 days). In two-thirds of patients, the lesion demonstrated on SPET was larger than that on CT, and this was especially so with older infarcts. Crossed cerebellar diaschisis occurred in 69% of patients. The high sensitivity of 201Tl-DDC SPET in the first 24 h after ischaemic stroke and the favourable properties of this radiopharmaceutical make it a method of interest in the assessment of initial perfusion defects in early experimental stroke therapies.
35例急性缺血性脑卒中患者在入院后24小时内接受了铊201二乙二硫代氨基甲酸盐单光子发射断层扫描（201Tl-DDC SPET）和X线计算机断层扫描（CT）检查。201Tl-DDC是一种非再分布剂，允许在早期给药和早期治疗干预后延迟成像。16例患者在卒中发作后24小时内进行了这两项检查。当以脑沟低密度和消失作为CT读片标准时，SPET在前24小时的敏感性为94%，CT为81%。当仅以低密度作为标准时，该组CT的敏感性为50%。在梗死时间较长（1-18天）的患者中，CT与SPET相比的敏感性越来越好。在三分之二的患者中，SPET显示的病变大于CT显示的病变，在梗死时间较长的患者中尤其如此。69%的患者出现交叉性小脑失联络。201Tl-DDC SPET在缺血性卒中后24小时内的高敏感性以及这种放射性药物的良好特性使其成为早期实验性卒中治疗中评估初始灌注缺损的一种有意义的方法。
