Lee R G, Hill T C, Holman B L, Clouse M E
Radiology. 1982 Dec;145(3):795-9. doi: 10.1148/radiology.145.3.6983089.
Transmission computed tomography (CT) brain scans were compared with N-isopropyl (I-123)-p-iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) brain scans to determine if there was a correlation between morphology, as seen on CT, and cerebral perfusion changes detected by IMP SPECT. In 12 patients with acute stroke, four showed no discordance between the edema seen on CT and perfusion deficits seen on IMP SPECT; five had positive IMP scans while initial CT scans were negative and follow-up CT scans demonstrated edema in the region of perfusion deficit seen on the IMP scans; and in four patients, the average perfusion deficit was 2.3 times greater than the edema shown on CT at 2 cm above the canthal-meatal line. In nine control patients, there was a 2.3% difference in IMP activity between the right and left hemispheres. The 12 stroke patients showed 30.3% less IMP activity in the abnormal hemisphere compared with the normal side. Three patients, one with temporal lobe seizure, one with hemiballismus, and the third with idiopathic intention tumor, had 54% greater IMP activity on the side of movement or seizure than on the normal side. The discordance between IMP and CT scans was clearly demonstrated in cases in which CT showed no abnormality but IMP provided information on function, reflected in increased or decreased cerebral perfusion.
将计算机断层扫描（CT）脑部扫描结果与N-异丙基（I-123）-对碘安非他明（IMP）单光子发射计算机断层扫描（SPECT）脑部扫描结果进行比较，以确定CT所见形态与IMP SPECT检测到的脑灌注变化之间是否存在相关性。在12例急性中风患者中，4例CT上所见水肿与IMP SPECT上所见灌注缺损之间无不一致；5例IMP扫描呈阳性，而初始CT扫描为阴性，随访CT扫描显示在IMP扫描所见灌注缺损区域有水肿；4例患者在眦耳线以上2 cm处，平均灌注缺损比CT上显示的水肿大2.3倍。在9例对照患者中，左右半球之间的IMP活性差异为2.3%。12例中风患者异常半球的IMP活性比正常侧低30.3%。3例患者，1例患有颞叶癫痫，1例患有偏身投掷症，第3例患有特发性意向性震颤，其运动或癫痫发作侧的IMP活性比正常侧高54%。在CT显示无异常但IMP提供功能信息（表现为脑灌注增加或减少）的病例中，IMP与CT扫描之间的不一致得到了清楚的证明。
