Wang Jun-jun, Zhang Chun-ni, Meng Yang, Han Ai-zhong, Gong Jian-bin, Li Ke
Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China.
Clin Chim Acta. 2009 Oct;408(1-2):79-82. doi: 10.1016/j.cca.2009.07.013. Epub 2009 Jul 29.
To investigate possible mechanisms and association of increased oxidized Lp(a) [ox-Lp(a)] levels with presence and extent of acute coronary syndromes (ACS).
Ox-Lp(a) levels were studied in 96 patients with ACS, 89 patients with stable coronary artery disease (CAD), and 100 control subjects.
Compared to control, ox-Lp(a) levels increased in stable CAD patients (P<0.001), and especially in ACS (P<0.001) (ACS, 16.29+/-13.80 microg/ml; stable CAD, 10.04+/-10.32 microg/ml; control, 7.10+/-9.16 microg/ml). The ratio of ox-Lp(a) to Lp(a) was higher in the ACS than those in the stable CAD (P<0.05) and control (P<0.001). Ox-Lp(a) levels were found associated with a graded increase in extent of angiographically documented CAD in the ACS (R=0.275, P=0.007), while not in the stable CAD (R=0.090, P=0.402). Multiple linear regression analysis found ox-Lp(a) (beta=0.271, P=0.019), age (beta=0.244, P=0.038) and TG (beta=0.213, P=0.070) accounted for 11.1% of the variation in the extent of angiographically documented CAD in ACS patients; Lp(a) (beta=0.415, P=0.000) and extent of CAD (beta=0.193, P=0.071) accounted for 21.5% of that in ox-Lp(a) levels.
Elevated ox-Lp(a) levels are associated with presence and severity of ACS, and may be useful for identification of patients with ACS.
探讨氧化型脂蛋白(a)[ox-Lp(a)]水平升高与急性冠脉综合征(ACS)的存在及严重程度之间的可能机制及关联。
对96例ACS患者、89例稳定型冠心病(CAD)患者和100例对照者的ox-Lp(a)水平进行了研究。
与对照组相比，稳定型CAD患者的ox-Lp(a)水平升高(P<0.001)，尤其是ACS患者(P<0.001)(ACS组为16.29±13.80μg/ml；稳定型CAD组为10.04±10.32μg/ml；对照组为7.10±9.16μg/ml)。ACS患者的ox-Lp(a)与Lp(a)的比值高于稳定型CAD患者(P<0.05)和对照组(P<0.001)。发现ACS患者中ox-Lp(a)水平与血管造影记录的CAD严重程度分级增加相关(R=0.275，P=0.007)，而在稳定型CAD患者中无此相关性(R=0.090，P=0.402)。多元线性回归分析发现，ox-Lp(a)(β=0.271，P=0.019)、年龄(β=0.244，P=0.038)和甘油三酯(TG)(β=0.213，P=0.070)占ACS患者血管造影记录的CAD严重程度变化的11.1%；Lp(a)(β=0.415，P=0.000)和CAD严重程度(β=0.193，P=0.071)占ox-Lp(a)水平变化的21.5%。
ox-Lp(a)水平升高与ACS的存在及严重程度相关，可能有助于识别ACS患者。
