Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China.
Clin Biochem. 2010 Apr;43(6):571-5. doi: 10.1016/j.clinbiochem.2009.12.017. Epub 2010 Jan 7.
To evaluate clinical value of oxidized lipoprotein(a) [ox-Lp(a)] levels.
Ox-Lp(a) were measured by 2 ELISAs using antibodies against ox-Lp(a) [ox-Lp(a)1] or oxidized low-density lipoprotein [ox-Lp(a)2], and studied in 161 acute coronary syndromes (ACS) patients, 114 stable coronary artery disease (CAD) and 100 control subjects.
Ox-Lp(a)1 was found related with ox-Lp(a)2 (r=0.864, P=0.000). Controlling for plasma lipids, Lp(a) and clinical characteristics, odds ratios of ox-Lp(a)1 on ACS and stable CAD were 5.06 (95% confidence interval 1.82-14.04) and 2.20 (0.78-6.22); those of ox-Lp(a)2 were 3.37 (1.07-10.63) and 1.35 (0.41-4.48), respectively. Receiver-operating characteristic curve analysis confirmed that performances of ox-Lp(a)1 were significantly superior to those for ox-Lp(a)2 in ACS (area: 0.803 vs. 0.723, P<0.001) and stable CAD (area: 0.670 vs. 0.607, P<0.01).
Ox-Lp(a) levels using antibodies against ox-Lp(a) may represent a better risk marker than those using antibodies against oxidized low-density lipoprotein for ACS and stable CAD.
评估氧化脂蛋白(a) [ox-Lp(a)]水平的临床价值。
使用针对 ox-Lp(a) [ox-Lp(a)1]或氧化型低密度脂蛋白 [ox-Lp(a)2]的 2 种 ELISA 法测量 ox-Lp(a)，并在 161 例急性冠脉综合征 (ACS)患者、114 例稳定型冠心病 (CAD)患者和 100 例对照者中进行研究。
发现 ox-Lp(a)1 与 ox-Lp(a)2 相关 (r=0.864，P=0.000)。在校正血浆脂质、Lp(a)和临床特征后，ox-Lp(a)1 对 ACS 和稳定型 CAD 的比值比分别为 5.06 (95%置信区间 1.82-14.04)和 2.20 (0.78-6.22)；ox-Lp(a)2 的比值比分别为 3.37 (1.07-10.63)和 1.35 (0.41-4.48)。受试者工作特征曲线分析证实，ox-Lp(a)1 在 ACS (曲线下面积：0.803 比 0.723，P<0.001)和稳定型 CAD (曲线下面积：0.670 比 0.607，P<0.01)中的性能明显优于 ox-Lp(a)2。
针对 ox-Lp(a)的抗体检测 ox-Lp(a)水平可能比针对氧化型低密度脂蛋白的抗体检测 ox-Lp(a)水平更能作为 ACS 和稳定型 CAD 的更好风险标志物。
