肝性脑病

Hepatic encephalopathy.

作者信息

Eroglu Yasemen, Byrne William J

机构信息

Division of Pediatric Gastroenterology, Department of Pediatrics, Oregon Health & Science University, CDRCP, Portland, OR 97239, USA.

出版信息

Emerg Med Clin North Am. 2009 Aug;27(3):401-14. doi: 10.1016/j.emc.2009.04.005.

DOI:10.1016/j.emc.2009.04.005

PMID:19646644

Abstract

Hepatic encephalopathy is characterized by a wide spectrum of neuropsychiatric abnormalities and motor disturbances in patients with advanced liver disease. It is estimated to occur in 30% to 45% of patients with liver cirrhosis and in 10% to 50% of patients with transjugular intrahepatic portosystemic shunts. It can be seen in cancer patients due to multiple factors. Early diagnosis and treatment are important but can be challenging, especially in mild forms with subtle findings. This article reviews the pathogenesis, diagnostic criteria, grading, and management of hepatic encephalopathy.

摘要

肝性脑病的特征是晚期肝病患者出现广泛的神经精神异常和运动障碍。据估计，肝硬化患者中30%至45%会发生肝性脑病，经颈静脉肝内门体分流术患者中10%至50%会发生。由于多种因素，癌症患者也可出现肝性脑病。早期诊断和治疗很重要，但可能具有挑战性，尤其是在症状轻微、表现不明显的情况下。本文综述了肝性脑病的发病机制、诊断标准、分级及管理。