所有回收卵母细胞中均存在滑面内质网聚集，导致反复出现多种异常：病例报告。
Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.
作者信息
Akarsu Cem, Çağlar Gamze, Vicdan Kubilay, Sözen Eran, Biberoğlu Kutay
机构信息
Ankara Private IVF Center, Ankara, Turkey.
Ankara Private IVF Center, Ankara, Turkey; Present address: Department of Obstetrics and Gynecology, Ufuk University Faculty of Medicine, Ankara, Turkey.
出版信息
Fertil Steril. 2009 Oct;92(4):1496.e1-1496.e3. doi: 10.1016/j.fertnstert.2009.06.048. Epub 2009 Jul 30.
OBJECTIVE
To document the relationship between smooth endoplasmic reticulum (SER) aggregations and recurrent fetal anomalies.
DESIGN
Case report.
SETTING
Private IVF center.
PATIENT(S): A 28-year-old woman with an 11-year history of primary infertility.
INTERVENTION(S): Three consecutive cycles of intracytoplasmic sperm injection (ICSI) in the same patient.
MAIN OUTCOME MEASURE(S): Clinical pregnancy, live birth, fetal anomaly.
RESULT(S): In three consecutive ICSI cycles, a total of 59 MII oocytes were retreived in the same patient, all displaying SER aggregations. The fertilization rate per cycle was 80%, 50%, and 42%, respectively. A total of 12 embryos were transferred in three ICSI cycles, of which 11 were grade 1 embryos. Two of the three cycles ended up with clinical ongoing pregnancies but with multiple fetal anomalies.
CONCLUSION(S): This is the first case reported with SER aggregations in all retrieved oocytes in three consecutive ICSI cycles. The repetetive multiple fetal anomalies possibly related to oocyte dysmorphism are of concern.
目的
记录滑面内质网（SER）聚集与复发性胎儿异常之间的关系。
设计
病例报告。
地点
私立体外受精中心。
患者
一名有11年原发性不孕病史的28岁女性。
干预措施
对同一患者连续进行三个周期的卵胞浆内单精子注射（ICSI）。
主要观察指标
临床妊娠、活产、胎儿异常。
结果
在连续三个ICSI周期中，同一患者共获取59个第二次减数分裂中期（MII）卵母细胞，均显示有SER聚集。每个周期的受精率分别为80%、50%和42%。在三个ICSI周期中共移植12个胚胎，其中11个为1级胚胎。三个周期中有两个最终临床持续妊娠，但伴有多发胎儿异常。
结论
这是首例报道在连续三个ICSI周期中所有获取的卵母细胞均有SER聚集的病例。与卵母细胞发育异常可能相关的重复性多发胎儿异常令人担忧。
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