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醋酸格拉替雷通过扩增多发性硬化症患者中幼稚 CD4+CD25+FOXP3+CD31+T 细胞来改善调节性 T 细胞功能。

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4(+)CD25(+)FOXP3(+)CD31(+) T-cells in patients with multiple sclerosis.

机构信息

Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Germany.

出版信息

J Neuroimmunol. 2009 Nov 30;216(1-2):113-7. doi: 10.1016/j.jneuroim.2009.06.011. Epub 2009 Jul 31.

DOI:10.1016/j.jneuroim.2009.06.011
PMID:19646767
Abstract

Naturally occurring regulatory T-cells (Treg) exhibit impaired function in patients with relapsing-remitting multiple sclerosis (RRMS) resulting from an age-inappropriate disproportion between prevalences of newly generated CD31-coexpressing naive Treg and long-lived memory Treg in the periphery. Recent evidence suggests that the immunomodulatory action of glatiramer acetate (GA) includes effects on Treg function and frequencies. We prospectively assessed suppressive activities and frequencies of Treg and Treg subsets in 15 patients with RRMS undergoing long-term therapy with GA. Treatment for up to six months reconstituted naive Treg and increased total Treg numbers with concomitant reversion of the Treg defect.

摘要

自然发生的调节性 T 细胞 (Treg) 在复发缓解型多发性硬化症 (RRMS) 患者中表现出功能受损，这是由于外周血中新生 CD31 共表达幼稚 Treg 和长寿记忆性 Treg 的比例失衡，这种失衡与年龄有关。最近的证据表明，醋酸格拉替雷 (GA) 的免疫调节作用包括对 Treg 功能和频率的影响。我们前瞻性评估了 15 例接受 GA 长期治疗的 RRMS 患者 Treg 和 Treg 亚群的抑制活性和频率。长达 6 个月的治疗可重建幼稚 Treg，并增加总 Treg 数量，同时纠正 Treg 缺陷。

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Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4(+)CD25(+)FOXP3(+)CD31(+) T-cells in patients with multiple sclerosis.醋酸格拉替雷通过扩增多发性硬化症患者中幼稚 CD4+CD25+FOXP3+CD31+T 细胞来改善调节性 T 细胞功能。
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