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Inhibition of p300 and nuclear factor-kappaB by curcumin and its role in diabetic nephropathy.

作者信息

Kurien Biji T

出版信息

Nutrition. 2009 Sep;25(9):973-4; author reply 975-6. doi: 10.1016/j.nut.2009.04.019.

DOI:10.1016/j.nut.2009.04.019
PMID:19647625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2772822/
Abstract
摘要

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Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB.姜黄素通过抑制p300和核因子-κB来预防糖尿病相关的肾脏异常。
Nutrition. 2009 Sep;25(9):964-72. doi: 10.1016/j.nut.2008.12.007. Epub 2009 Mar 5.
2
Increasing the solubility of the nutraceutical curcumin by heat and inhibition of oxidative modification.通过加热提高营养保健品姜黄素的溶解度并抑制氧化修饰。
Mol Nutr Food Res. 2009 Feb;53(2):308. doi: 10.1002/mnfr.200990003.
3
Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability.在提高生物利用度的临床试验中应考虑使用热溶解姜黄素。
Clin Cancer Res. 2009 Jan 15;15(2):747; author reply 747. doi: 10.1158/1078-0432.CCR-08-1957.
4
Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures.二甲基亚砜(DMSO)对耳蜗器官型培养物的细胞毒性作用。
Hear Res. 2008 Feb;236(1-2):52-60. doi: 10.1016/j.heares.2007.12.002. Epub 2007 Dec 15.
5
Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO).极低浓度的常用药物递送载体二甲基亚砜(DMSO)对脑代谢的调节作用。
J Neurosci Res. 2008 Jan;86(1):208-14. doi: 10.1002/jnr.21477.
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Improving the solubility and pharmacological efficacy of curcumin by heat treatment.通过热处理提高姜黄素的溶解度和药理功效。
Assay Drug Dev Technol. 2007 Aug;5(4):567-76. doi: 10.1089/adt.2007.064.
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Responses of human lens epithelial cells to quercetin and DMSO.人晶状体上皮细胞对槲皮素和二甲基亚砜的反应。
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J Immunol Methods. 2005 Aug;303(1-2):66-75. doi: 10.1016/j.jim.2005.05.012.