Inserm, EMI-U0107, Paris, France.
Diabetes Metab. 2009 Nov;35(5):364-70. doi: 10.1016/j.diabet.2009.02.007. Epub 2009 Aug 3.
This study aimed to investigate the role played by sympathovagal balance in arterial stiffness, a common feature of insulin resistance and type 2 diabetes.
We investigated the relationship between autonomic nervous system activity and arterial stiffness in Zucker diabetic fatty rats (ZDF: Gmi-fa/fa) and their age-matched controls (lean: ?/fa). Using simultaneous catheterization of the proximal and distal aorta, we measured intra-arterial blood pressure (BP), heart rate (HR), their variability (spectral analysis) and aortic pulse wave velocity (PWV) in a series of at least six conscious rats aged 6, 12, 18 and 24 weeks.
BP and PWV increased with age (P<0.001) in both strains with no differences between strains, despite the insulin resistance already present at 6 weeks in ZDF rats. HR was significantly lower (P<0.001) in ZDF than in lean rats. In ZDF compared with lean rats, the low-frequency (LF) component of the systolic BP variations and the LF/high-frequency (HF) component of the pulse interval (PI) variation ratio were reduced (P<0.01 and P<0.05, respectively), while the HF component of the PI (HF-PI) variation was raised (P<0.05). PWV was negatively correlated with HF-PI (r=-0.37, P<0.01), but not with biochemical parameters. HF-PI was an independent variable explaining the variation in PWV.
During the development of disease of ZDF rats, sympathovagal balance might account for the lack of increase in PWV.
本研究旨在探讨自主神经平衡在动脉僵硬度中的作用，动脉僵硬度是胰岛素抵抗和 2 型糖尿病的共同特征。
我们研究了自主神经系统活动与 Zucker 糖尿病肥胖大鼠（ZDF：Gmi-fa/fa）及其同龄对照（瘦型：?/fa）动脉僵硬度之间的关系。通过对升主动脉和降主动脉进行同时导管插入术，我们测量了至少六只清醒大鼠的动脉内血压（BP）、心率（HR）、其变异性（频谱分析）和主动脉脉搏波速度（PWV），这些大鼠的年龄分别为 6、12、18 和 24 周。
在两种大鼠中，BP 和 PWV 均随年龄增长而增加（P<0.001），尽管 ZDF 大鼠在 6 周时已经存在胰岛素抵抗，但两种大鼠之间没有差异。ZDF 大鼠的 HR 明显低于瘦型大鼠（P<0.001）。与瘦型大鼠相比，ZDF 大鼠的收缩压变化的低频（LF）成分和脉搏间隔（PI）变化的 LF/高频（HF）成分比值降低（P<0.01 和 P<0.05），而 PI 的高频（HF-PI）成分升高（P<0.05）。PWV 与 HF-PI 呈负相关（r=-0.37，P<0.01），但与生化参数无关。HF-PI 是解释 PWV 变化的独立变量。
在 ZDF 大鼠疾病发展过程中，交感神经-副交感神经平衡可能是 PWV 增加的原因。
