Freitag Nancy E, Port Gary C, Miner Maurine D
Department of Microbiology and Immunology (MC790), University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 606127344, USA.
Nat Rev Microbiol. 2009 Sep;7(9):623-8. doi: 10.1038/nrmicro2171. Epub 2009 Aug 3.
Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.
单核细胞增生李斯特菌是一种作为腐生菌生活在土壤中的细菌，但在被易感人类或动物摄入后能够转变为病原体。最近的研究表明，单核细胞增生李斯特菌通过利用一系列环境线索（包括可用碳源）来精细调节一种名为PrfA的毒力调节蛋白的活性，从而介导其从腐生菌到胞质寄生虫的转变。在这篇进展文章中，我们描述了PrfA的调节及其在单核细胞增生李斯特菌从腐生阶段转变为致病细胞内阶段中的作用。
