Department of Molecular Biology; Molecular Infection Medicine, Sweden (MIMS); Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Bacterial Stress Response Group, Microbiology, School of Natural Sciences, National University of Ireland Galway, Galway H91 TK33, Ireland.
Microbiology (Reading). 2019 Aug;165(8):819-833. doi: 10.1099/mic.0.000808. Epub 2019 May 20.
In contrast to obligate intracellular pathogens that can remain in relatively stable host-associated environments, the soil-living bacterial pathogen Listeria monocytogenes has to sense and respond to physical and chemical cues in a variety of quite different niches. In particular, the bacterium has to survive the dramatic transition from its saprophytic existence to life within the host where nutritional stress, increased temperature, acidity, osmotic stress and the host defences present a new and challenging landscape. This review focuses on the σ and PrfA regulatory systems used by L. monocytogenes to sense the changing environment and implement survival mechanisms that help to overcome the disparate conditions within the host, but also to switch from a harmless saprophyte to an impressively effective pathogen.
与只能在相对稳定的宿主相关环境中生存的专性细胞内病原体不同，土壤生活的细菌病原体李斯特菌必须感知和响应各种截然不同的小生境中的物理和化学线索。特别是，细菌必须从腐生生存状态过渡到宿主内部的生活，在宿主内部，营养压力、温度升高、酸度、渗透压和宿主防御构成了一个新的具有挑战性的环境。这篇综述重点介绍了李斯特菌用于感知环境变化并实施生存机制的 σ 和 PrfA 调节系统，这些机制有助于克服宿主内的不同条件，但也有助于从无害的腐生菌转变为令人印象深刻的有效病原体。
