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同源配对：确保正确无误。

Homologue pairing: getting it right.

作者信息

Hawley R Scott, Gilliland William D

机构信息

Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

出版信息

Nat Cell Biol. 2009 Aug;11(8):917-8. doi: 10.1038/ncb0809-917.

DOI:10.1038/ncb0809-917
PMID:19648975
Abstract

In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enriched within these regions have now been identified. By recruiting their cognate ZnF-bearing proteins, these regions promote pairing and synapsis.

摘要

在秀丽隐杆线虫中，同源配对由每条染色体一端附近的特殊区域与含锌指（ZnF）蛋白共同介导。现已鉴定出在这些区域富集的重复序列家族。通过招募其同源的含锌指蛋白，这些区域促进配对和联会。

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本文引用的文献

1
Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.秀丽隐杆线虫中介导减数分裂配对和联会的染色体序列基序的鉴定。
Nat Cell Biol. 2009 Aug;11(8):934-42. doi: 10.1038/ncb1904. Epub 2009 Jul 20.
2
Homolog pairing and segregation in Drosophila meiosis.果蝇减数分裂中的同源配对和分离。
Genome Dyn. 2009;5:56-68. doi: 10.1159/000166619.
3
Homologue pairing, recombination and segregation in Caenorhabditis elegans.秀丽隐杆线虫中的同源配对、重组和分离
跨染色体的G-四链体形成序列的计算分析揭示了末端附近的高密度模式。
PLoS One. 2016 Oct 24;11(10):e0165101. doi: 10.1371/journal.pone.0165101. eCollection 2016.
4
Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.减数分裂过程中配对的缺失会引发秀丽隐杆线虫多代转基因沉默。
Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2667-76. doi: 10.1073/pnas.1501979112. Epub 2015 May 4.
Genome Dyn. 2009;5:43-55. doi: 10.1159/000166618.
4
Chromosome mechanics and meiotic engine maintenance.染色体机制与减数分裂引擎维持
PLoS Genet. 2008 Sep 26;4(9):e1000210. doi: 10.1371/journal.pgen.1000210.
5
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.SUN1是小鼠端粒附着于核膜及配子发生所必需的。
Dev Cell. 2007 Jun;12(6):863-72. doi: 10.1016/j.devcel.2007.03.018.
6
A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans.秀丽隐杆线虫减数分裂过程中，染色体特异性配对和联会需要一个锌指蛋白家族。
Dev Cell. 2006 Dec;11(6):817-29. doi: 10.1016/j.devcel.2006.09.020.
7
The meiotic chromosomal bouquet: SUN collects flowers.减数分裂染色体花束：SUN蛋白收集“花朵”。
Cell. 2006 Apr 7;125(1):19-21. doi: 10.1016/j.cell.2006.03.020.
8
HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis.HIM-8与X染色体配对中心结合并介导染色体特异性减数分裂联会。
Cell. 2005 Dec 16;123(6):1051-63. doi: 10.1016/j.cell.2005.09.035.
9
Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans.在秀丽隐杆线虫减数分裂过程中，染色体位点在建立同源联会方面发挥着双重作用。
Cell. 2005 Dec 16;123(6):1037-50. doi: 10.1016/j.cell.2005.09.034.
10
Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans.在秀丽隐杆线虫减数分裂前期，依赖联会和不依赖联会的机制稳定同源染色体配对。
Genes Dev. 2002 Sep 15;16(18):2428-42. doi: 10.1101/gad.1011602.