HORMA 结构域位于减数分裂染色体动力学的核心。
HORMA domains at the heart of meiotic chromosome dynamics.
机构信息
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, 45117 Essen, Germany.
出版信息
Dev Cell. 2014 Nov 24;31(4):389-91. doi: 10.1016/j.devcel.2014.11.009.
HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.
HORMA 结构域蛋白对于减数分裂过程中染色体组织的精确调控至关重要。Kim 等人（2014 年）和 Silva 等人（2014 年）现在提供了线虫 HORMA 蛋白作用的结构和功能见解，揭示了与有丝分裂检验点信号传导中 HORMA 蛋白 MAD2 功能的相似性。
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