Zhang Jun, Li Jin-zhao, Wang Zhi-ming, Zhang Li-ping
Department of Stomatology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Shanghai Kou Qiang Yi Xue. 2009 Jun;18(3):243-6.
To investigate the changes and the significance of caveolin-1 gene and protein in tongue squamous cell carcinoma(TSCC).
Immunohistochemical staining and in situ hybridization were used to detect the changes of caveolin-1 gene and the protein in 92 TSCCs and their adjacent normal tissues. The data were analyzed with SPSS10.0 software package.
The expressions of caveolin-1 gene(24.6+/-1.8) and its protein(471.2+/-68.1) in TSCC were lower than those of the control group(167.2+/-20.5, 964.5+/-77.2), respectively. The difference was significant(P<0.01). The expression of caveolin-1 protein in well-differentiated TSCC(5.6+/-1.4) was higher than that in moderately and poorly differentiated TSCC(1.3+/-0.8); The expression of caveolin-1 protein in stage I-II patients(6.1+/-2.0) was higher than that in stage III-IV patients(2.4+/-0.7), and the difference was significant(P<0.01). There was no significant relationship between the expression of caveolin-1 protein and cervical lymph node metastasis(P>0.05).
The level of caveolin-1 gene and the expression of the protein decrease in TSCC and the level of protein has a significant relationship with the clinical stage and the pathological grade, rather than the cervical lymph node metastasis.
探讨小窝蛋白-1基因及蛋白在舌鳞状细胞癌（TSCC）中的变化及意义。
采用免疫组织化学染色和原位杂交法检测92例TSCC组织及其癌旁正常组织中小窝蛋白-1基因及蛋白的变化。数据用SPSS10.0软件包进行分析。
TSCC组织中小窝蛋白-1基因表达水平（24.6±1.8）及蛋白表达水平（471.2±68.1）均低于对照组（167.2±20.5，964.5±77.2），差异有统计学意义（P<0.01）。高分化TSCC组织中小窝蛋白-1蛋白表达水平（5.6±1.4）高于中、低分化TSCC组织（1.3±0.8）；Ⅰ-Ⅱ期患者小窝蛋白-1蛋白表达水平（6.1±2.0）高于Ⅲ-Ⅳ期患者（2.4±0.7），差异有统计学意义（P<0.01）。小窝蛋白-1蛋白表达与颈部淋巴结转移无明显相关性（P>0.05）。
TSCC组织中小窝蛋白-1基因水平及蛋白表达降低，且蛋白水平与临床分期及病理分级密切相关，与颈部淋巴结转移无关。
