Child and Adolescent Department, University Hospital of Geneva, 6 rue Willy-Donzé, 1211 Geneva, Switzerland.
Eur J Pediatr. 2010 Mar;169(3):319-25. doi: 10.1007/s00431-009-1032-y. Epub 2009 Aug 4.
Rotavirus gastroenteritis (RV GE) is a leading cause of diarrhoea in young children. The purpose of this epidemiological surveillance was to measure the disease burden of RV GE among children <5 years of age in two regions of Switzerland, Geneva and Lucerne. One hospital and four paediatricians participated per region. The surveillance lasted from December 2006 to June 2007. The population denominator for calculation of the RV GE incidence rate was the average of the overall study population <5 years of age under surveillance during the surveillance period. At the study sites, 513 children with GE were presented. Stool sample was collected and examined in 341 cases, of which 130 were RV positive (38.1%). Informed consent to participate in the study was obtained for 113 RV positive subjects. The overall RV GE incidence rate was 0.97% in Lucerne [lower incidence interval (LCI), 0.71%; upper incidence interval (UCI), 1.2%] compared with 0.65 and in Geneva (LCI, 0.50%; UCI, 0.81%). Disease severity assessments using the Vescari score showed that the RV GE episodes were more severe in Lucerne than in Geneva (14.05 +/- 3.05 vs 12.85 +/- 2.87), which was confirmed by a higher hospitalisation rate in Lucerne at the study visit (82.9% vs 23.6%). More children had fever in Geneva than in Lucerne (42.9% vs 26.8%), and more children were hospitalised during the follow-up period in Geneva than in Lucerne (14.5% vs 2.5%). Genotyping of RV positive stool samples revealed that both G1 and P8 were the most prevalent types in both regions. There was a statistically significant difference in the distribution frequency of G1 between the two regions (p = 0.039). Assessment of health economic data confirmed the economic burden of RV GE episodes. In conclusion, RV GE episodes are a health burden as well as an economic burden also for the children in a developed country such as Switzerland.
轮状病毒胃肠炎（RVGE）是导致幼儿腹泻的主要原因。本次流行病学监测的目的是测量瑞士日内瓦和卢塞恩两个地区 5 岁以下儿童的 RVGE 疾病负担。每个地区有一家医院和四位儿科医生参与。监测时间为 2006 年 12 月至 2007 年 6 月。RVGE 发病率的计算人口基数为监测期间接受监测的 5 岁以下总体研究人群的平均值。在研究地点，有 513 例 GE 患儿就诊。收集了 341 例粪便样本进行检查，其中 130 例 RV 阳性（38.1%）。对 113 例 RV 阳性患儿获得了参与研究的知情同意。卢塞恩的总 RVGE 发病率为 0.97%（下限区间 [LCI]，0.71%；上限区间 [UCI]，1.2%），而日内瓦为 0.65%（LCI，0.50%；UCI，0.81%）。使用 Vescari 评分进行疾病严重程度评估显示，卢塞恩的 RVGE 发作比日内瓦更严重（14.05 +/- 3.05 比 12.85 +/- 2.87），这一点通过研究就诊时卢塞恩更高的住院率得到了证实（82.9%比 23.6%）。日内瓦的发热患儿多于卢塞恩（42.9%比 26.8%），日内瓦的住院患儿也多于卢塞恩（14.5%比 2.5%）。对 RV 阳性粪便样本进行基因分型显示，G1 和 P8 两种基因型在两个地区均为最常见类型。两个地区的 G1 分布频率存在统计学差异（p = 0.039）。对卫生经济学数据的评估证实了 RVGE 发作的经济负担。总之，RVGE 发作不仅是健康负担，也是发达国家（如瑞士）儿童的经济负担。
