a Pediatrics; Mafraq Hospital; Abu Dhabi, UAE.
Hum Vaccin Immunother. 2014;10(8):2284-9. doi: 10.4161/hv.29386.
Rotavirus (RV) is the most common etiological agent causing acute gastroenteritis (GE) in children aged <5 years. This cross-sectional, hospital-based surveillance study (NCT01201252) was designed to investigate RVGE disease burden. It was conducted from July 2009-July 2010 at 3 referral hospitals in the United Arab Emirates (UAE). Children who had been hospitalized for acute GE were enrolled with informed consent. Stool samples were tested for RV using enzyme immunoassay and RV-positive samples were further typed using reverse transcriptase-polymerase chain reaction and reverse hybridization to determine the G and P types. GE data were collected from medical charts and GE severity was assessed through clinical examination. Treatment and outcome were prospectively recorded. Among 6323 children hospitalized due to any reason, 771 (12.2%) presented acute GE and were enrolled, of whom 758 (98.3%) were included in the final analysis. Acute GE and RVGE accounted for 12.0% (758/6323) and 6.0% (381/6323) of all hospitalizations, respectively. RVGE accounted for 50.3% (381/758) of GE hospitalizations and predominantly affected, children younger than 2 years (66.1%; 252/381). The severity of GE before hospitalization was significantly associated with RV-positive status (P = 0.0031). The majority (>95%) of children received intravenous hydration during hospitalization. RVGE occurred throughout the year, with a subtle winter peak in February 2010 (63.6%; 56/88). G1WTP[8]WT was the most commonly detected RV strain (56.3%) in 268 analyzed samples. RV was a major cause of GE-hospitalizations in children under 5 years in the UAE; the highest number of RVGE cases was observed in children younger than 2 years.
轮状病毒（RV）是导致<5 岁儿童急性肠胃炎（GE）的最常见病因。本项横断面、医院为基础的监测研究（NCT01201252）旨在调查 RVGE 的疾病负担。研究于 2009 年 7 月至 2010 年 7 月在阿拉伯联合酋长国（UAE）的 3 家转诊医院进行。研究入组的患儿均因急性 GE 住院，并获得了知情同意。采用酶联免疫吸附试验检测粪便 RV，对 RV 阳性样本进一步采用逆转录-聚合酶链反应和反向杂交进行 RV 定型，以确定 G 和 P 型。从病历中收集 GE 数据，通过临床检查评估 GE 严重程度。前瞻性记录治疗和结局。在因任何原因住院的 6323 例患儿中，771 例（12.2%）出现急性 GE 并被入组，其中 758 例（98.3%）被纳入最终分析。急性 GE 和 RVGE 分别占所有住院患儿的 12.0%（758/6323）和 6.0%（381/6323）。RVGE 占 GE 住院患儿的 50.3%（381/758），主要影响<2 岁的患儿（66.1%；252/381）。住院前 GE 的严重程度与 RV 阳性状态显著相关（P = 0.0031）。大多数（>95%）患儿在住院期间接受静脉补液。RVGE 全年均可发生，2010 年 2 月有一个轻微的冬季高峰（63.6%；56/88）。在 268 份分析样本中，最常检测到的 RV 株为 G1WTP[8]WT（56.3%）。RV 是 UAE 5 岁以下儿童 GE 住院的主要病因；<2 岁儿童的 RVGE 病例数最多。
