Netland P A, Townsend D J, Albert D M, Jakobiec F A
Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston 02115.
Ophthalmology. 1990 Dec;97(12):1593-8. doi: 10.1016/s0161-6420(90)32373-4.
Hidradenoma papilliferum is derived from apocrine sweat glands and was originally described as a tumor located in the anogenital area. The authors recently examined a 78-year-old man with a hidradenoma papilliferum at the margin of the upper eyelid. While the tumor was located in the dermis, serial sections showed a connection to the epidermis and neoplastic cells partially replacing a gland of Moll. There were glandular structures with luminal cells that showed apical decapitation-type secretion, indicating the apocrine origin of the tumor. The luminal cells also contained granules that stained with periodic acid-Schiff (PAS) stain and were diastase resistant. Results of examination of the duct-forming cells by transmission electron microscopy showed adluminal villi, focal decapitation secretion, luminal cytoplasmic debris, and electron-dense cytoplasmic secretory granules. Because the apocrine glands of Moll are localized adjacent to the eyelid cilia, hidradenoma papilliferum and other tumors of apocrine origin should be considered in the clinical setting of a mass at the eyelid margin.
乳头状汗腺瘤起源于顶泌汗腺，最初被描述为一种位于肛门生殖器区域的肿瘤。作者最近检查了一名78岁的男性，其在上睑边缘患有乳头状汗腺瘤。虽然肿瘤位于真皮层，但连续切片显示其与表皮相连，肿瘤细胞部分取代了Moll腺。存在具有管腔细胞的腺结构，这些管腔细胞显示出顶端断头型分泌，表明肿瘤起源于顶泌汗腺。管腔细胞还含有经高碘酸希夫（PAS）染色且抗淀粉酶的颗粒。通过透射电子显微镜检查导管形成细胞的结果显示有腔内绒毛、局灶性断头分泌、管腔细胞质碎片和电子致密的细胞质分泌颗粒。由于Moll顶泌腺位于眼睑睫毛附近，因此在眼睑边缘出现肿块的临床情况下，应考虑乳头状汗腺瘤和其他顶泌汗腺起源的肿瘤。
