Pervaiz Shazib, Taneja Reshma, Ghaffari Saghi
Department of Physiology, Yong Loo Lin School of Medicine , Singapore.
Antioxid Redox Signal. 2009 Nov;11(11):2777-89. doi: 10.1089/ars.2009.2804.
In recent years, it has become clear that balanced regulation of reactive oxygen species is of critical significance for cell-fate determination as well as for stem cell development, function, and survival. Although many questions regarding intracellular redox status regulation of stem cell fate remain, we review here what is known regarding the impact of cell-fate signaling as shown with a variety of human cancer cells and more recently on cancer-initiating cells and on the regenerative capacity of skeletal muscle and hematopoietic tissue and their stem cells. We also discuss the role of altered intracellular redox status as a potential primary pathogenic mechanism in muscular dystrophy and hematopoietic pathologies. Studies discussed here illustrate how understanding altered redox regulation of stem cell behavior may contribute to the development of novel stem cell therapies.
近年来，越来越清楚的是，活性氧的平衡调节对于细胞命运决定以及干细胞的发育、功能和存活至关重要。尽管关于干细胞命运的细胞内氧化还原状态调节仍有许多问题，但我们在此回顾一下已知的细胞命运信号传导的影响，这在多种人类癌细胞中已得到证实，最近在癌症起始细胞以及骨骼肌和造血组织及其干细胞的再生能力方面也有相关研究。我们还讨论了细胞内氧化还原状态改变作为肌肉营养不良和造血系统疾病潜在主要致病机制的作用。这里讨论的研究说明了理解干细胞行为的氧化还原调节改变如何可能有助于新型干细胞疗法的开发。
